1, 4-Chrysenequinone E 5729 Smiles: CC(=O)O[C@]12[C@H]3[C@@H](OC(=O)C4C=CC=CC=4)[C@](O)(C[C@H]3[C@]34[C@H]5C(OC)[C@H]1[C@H]3N(C[C@]5(COC)[C@H](O)C[C@@H]4OC)CC)[C@@H](OC)[C@@H]2O

Smiles: CC(=O)O[C@]12[C@H]3[C@@H](OC(=O)C4C=CC=CC=4)[C@](O)(C[C@H]3[C@]34[C@H]5C(OC)[C@H]1[C@H]3N(C[C@]5(COC)[C@H](O)C[C@@H]4OC)CC)[C@@H](OC)[C@@H]2O

PT2385 exhibits good mouse oral bioavailability (110%) and low to medium in vivo clearance

1-2H3/t18-

15(9)22)7-11(8-21)6-12-14-17(3

Zibotentan binds selectively to the ET-A receptor

1, 4-Chrysenequinone E 5729 Smiles: CC(=O)O[C@]12[C@H]3[C@@H](OC(=O)C4C=CC=CC=4)[C@](O)(C[C@H]3[C@]34[C@H]5C(OC)[C@H]1[C@H]3N(C[C@]5(COC)[C@H](O)C[C@@H]4OC)CC)[C@@H](OC)[C@@H]2O1,4 Chrysenequinone, a polycyclic aromatic quinone, acts as an activator of aryl hydrocarbon receptor (AhR). Product information CAS Number: 100900 16 1 Molecular Weight: 258. 27 Formula: C18H10O2 Synonym: Chrysene 1,4 dione Chemical Name: 1,4 dihydrochrysene 1,4 dione Smiles: O=C1C=CC(=O)C2C=CC3C4=CC=CC=C4C=CC=3C1=2 InChiKey: UORKIKBNUWJNJF UHFFFAOYSA N InChi: InChI=1S C18H10O2 c19 16 9 10 17(20)18 14 6 5 11 3 1 2 4 12(11)13(14)7 8 15(16)18 h1 10H